Which mutation arises from wobble in codon-anticodon pairing?

Which mutation arises from wobble in codon-anticodon pairing?

• A. Silent mutation
• B. Nonsense mutation
• C. Frameshift mutation
• D. Missense mutation

Answer: (A)

Wobble in codon-anticodon pairing means the third base of the codon can pair flexibly with multiple bases, and the genetic code is degenerate, so several codons encode the same amino acid. Because of this, a change at the wobble position often does not alter which amino acid is added, resulting in a silent mutation. For example, codons for the same amino acid often differ at the third base, so a single-base change there can leave the protein sequence unchanged. In contrast, frameshift mutations arise from insertions or deletions that shift the reading frame, nonsense mutations create a premature stop codon, and missense mutations change one amino acid to another. So the mutation arising from wobble is a silent mutation.

Wobble in codon-anticodon pairing means the third base of the codon can pair flexibly with multiple bases, and the genetic code is degenerate, so several codons encode the same amino acid. Because of this, a change at the wobble position often does not alter which amino acid is added, resulting in a silent mutation. For example, codons for the same amino acid often differ at the third base, so a single-base change there can leave the protein sequence unchanged. In contrast, frameshift mutations arise from insertions or deletions that shift the reading frame, nonsense mutations create a premature stop codon, and missense mutations change one amino acid to another. So the mutation arising from wobble is a silent mutation.